Comparison of Lewis–Sumner syndrome with chronic inflammatory demyelinating polyradiculoneuropathy patients in a tertiary care centre

• DOI: 10.1111/ene.14101
• Publication Date: 2019-10-01T19:34:00Z
• Authors: G. Fargeot; T. Maisonobe; D. Psimaras; R. Debs; T. Lenglet; D. Adams; C. Vandendries; C. Labeyrie; K. Viala
• Keywords: Polyradiculoneuropathy; Electromyoneurography

Background and purpose Whether the Lewis–Sumner syndrome (L‐SS) is a distinct entity from other types of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP‐ot) remains controversial. Method The clinical/electrophysiological characteristics long‐term outcomes 45 L‐SS 35 CIDP‐ot patients were retrospectively compared. Results group was composed 11 with typical CIDP, 17 pure sensory form, four distal form three motor form. In group, asymmetric ( P < 0.001) monomelic involvement = 0.04) upper limbs significantly more frequent; paucisymptomatic forms (Overall Neuropathy Limitations Scale ≤ 1) less frequent 0.001); electroneuromyography showed that conduction block in intermediate nerve segments main feature, F‐wave abnormalities on nerves without (44%). Long‐term prognosis globally poorer aggravation during treatment 0.02), withdrawal 0.03) longer time to achieve successful (39 vs. 15 months). Conclusions Our study suggests have favourable therapeutic response rate outcomes. Rapid differentiation CIDP important order anticipate complicated disease course management, one side inefficacy or even harmfulness corticosteroids difficult weaning procedure. A prospective necessary confirm these results.