Blood biomarkers and prognosis of amyotrophic lateral sclerosis

• DOI: 10.1111/ene.14409
• Publication Date: 2020-06-17T20:50:11Z
• Authors: J. Sun; J. J. Carrero; U. Zagai; M. Evans; C. Ingre; Y. Pawitan; F. Fang
• Keywords: Cohort Studies; Male; Sweden; 0301 basic medicine; 03 medical and health sciences; Amyotrophic Lateral Sclerosis; Humans; Female; Prognosis; Biomarkers; Aged; 3. Good health

The objective was to assess the ability of eight commonly measured blood markers serve as prognostic biomarkers in amyotrophic lateral sclerosis (ALS).A cohort study conducted 399 individuals with newly diagnosed ALS between 2006 and 2011 Stockholm, Sweden. Information on markers, including creatinine, albumin, haemoglobin, C-reactive protein (CRP), glucose, potassium, sodium calcium, at or after date diagnosis, collected. Cox regression model joint were used explore associations risk mortality.The mean age diagnosis 66.25 years 58% patients male. A lower than median level serum creatinine [hazard ratio (HR) 1.67; 95% confidence interval (CI) 1.31-2.12] albumin (HR 1.49, CI 1.13-1.96) whereas a higher log-transformed CRP 1.33, 1.04-1.71) glucose 1.34, 1.01-1.78) baseline associated mortality risk. Taking all available measurements into account, an association found per standard deviation (SD) decrease 2.23, 1.81-2.75) 1.83, 1.43-2.36) well SD increase log(CRP) 1.96, 1.58-2.43) 1.61, 1.21-2.12) No clear for calcium.This suggests that time their temporal changes could additional ALS. Their values routine clinical practice trials need be investigated further.