The severity of neuropsychiatric symptoms is higher in early‐onset than late‐onset Alzheimer’s disease

• DOI: 10.1111/ene.15203
• Publication Date: 2021-12-04T13:05:26Z
• Authors: Neus Falgàs; Isabel E. Allen; Salvatore Spina; Harli Grant; Stefanie D. Piña ...; Jennifer Merrilees; Rosalie Gearhart; Howard J. Rosen; Joel H. Kramer; William W. Seeley; Thomas C. Neylan; Bruce L. Miller; Gil D. Rabinovici; Lea T. Grinberg; Christine M. Walsh
• Keywords: Clinical Dementia Rating; Early-onset Alzheimer's disease

The faster rates of cognitive decline and predominance atypical forms in early-onset Alzheimer's disease (EOAD) suggest that neuropsychiatric symptoms could be different EOAD compared to late-onset AD (LOAD); however, prior studies based on non-biomarker-diagnosed cohorts show discordant results. Our goal was determine the profile LOAD, a cohort with biomarker/postmortem-confirmed diagnoses. Additionally, contribution co-pathologies explored.In all, 219 participants (135 EOAD, 84 LOAD) meeting National Institute Aging Association criteria for (115 amyloid positron emission tomography/cerebrospinal fluid biomarkers, 104 postmortem diagnosis) at University California San Francisco were evaluated. Neuropsychiatric Inventory-Questionnaire (NPI-Q) assessed baseline during follow-up. NPI-Q mean comparisons regression models adjusted by (Mini-Mental State Examination) functional status (Clinical Dementia Rating Sum Boxes) performed effect EOAD/LOAD amnestic/non-amnestic diagnosis NPI-Q. Regression assessing performed.At baseline, scores higher LOAD (p < 0.05). Longitudinally, showed significant diagnosis, where had total, anxiety, motor disturbances night-time behavior No differences between amnestics/non-amnestics found. Argyrophilic grain co-pathology predicted severity LOAD.Anxiety, behaviors are more severe than across course. differential patterns observed pattern selective vulnerability extending brain's subcortical structures. Further, such as argyrophilic may also play role increasing symptoms.