Levels and dynamics of estimated glomerular filtration rate and recurrent vascular events and death in patients with minor stroke or transient ischemic attack

• DOI: 10.1111/ene.15431
• Publication Date: 2022-06-02T13:50:25Z
• Authors: Serdar Tütüncü; Manuel C. Olma; Claudia Kunze; Michael Krämer; Joanna Dietzel; Johannes Schurig; Paula Filser; Waltraud Pfeilsch...; Gerhard F. Hamann; Thomas Büttner; Peter U. Heuschmann; Paulus Kirchhof; Ulrich Laufs; Darius G. Nabavi; Joachim Röther; Götz Thomalla; Roland Veltkamp; Kai‐Uwe Eckardt; Karl Georg Haeusler; Matthias Endres
• Keywords: Stroke

Impaired kidney function is associated with an increased risk of vascular events in acute stroke patients, when assessed by single measurements estimated glomerular filtration rate (eGFR). It unknown whether repeated provide additional information for prediction.The MonDAFIS (Systematic Monitoring Detection Atrial Fibrillation Patients Acute Ischemic Stroke) study randomly assigned 3465 ischemic patients to either standard procedures or additive Holter electrocardiogram. Baseline eGFR (CKD-EPI formula) were dichotomized into values < versus ≥60 ml/min/1.73 m2 . dynamics classified based on two in-hospital as "stable normal" (≥60 ), "increasing" (by at least 15% from baseline, second value ≥ 60 "decreasing" baseline and decreased" (<60 ). The composite endpoint (stroke, major bleeding, myocardial infarction, all-cause death) was after 24 months. We hazard ratios confounder-adjusted models.Estimated available 2947 a 1623 patients. After adjusting age, severity, cardiovascular factors, randomization, (hazard ratio [HR] = 2.2, 95% confidence interval [CI] 1.40-3.54) well decreasing (HR 1.79, CI 1.07-2.99) stable decreased 1.64, 1.20-2.24) independently the endpoint. In addition, ml/min/1.732 3.02, 1.51-6.10) death 3.12, 1.63-5.98).In addition low levels also those have death; hence, estimates might add relevant prediction.