Role of the high mobility group box 1 signalling axes via the receptor for advanced glycation end‐products and toll‐like receptor‐4 in the immunopathology of oral lichen planus: a potential drug target?

• DOI: 10.1111/eos.12416
• Publication Date: 2018-04-20T09:35:12Z
• Authors: Abdelhakim Salem; Rabeia Almahmoudi; Mari Vehviläinen; Tuula Salo
• Keywords: RAGE; Immunostaining; Proinflammatory cytokine; Oral Lichen Planus; HMGB1; High-mobility group

High mobility group box 1 ( HMGB 1) is an extremely conserved DNA ‐binding protein that stabilizes nucleosomes and facilitates gene transcription in mammalian cells. When released extracellularly, becomes alarmin can mediate systemic diseases. signals via two main receptors: receptor for advanced glycation end‐products RAGE ) toll‐like receptor‐4 TLR 4). We hypothesized expression increased patients with oral lichen planus OLP relative to healthy controls. Therefore, its receptors were mapped tissue biopsies from 25 20 controls by immunostaining ImageJ analysis. was induced keratinocytes all . The band‐like cell infiltrate revealed very strong staining Likewise, 4 overexpressed throughout mucosa which co‐localized 1. In conclusion, we suggest could partly be 1‐mediated condition creating a proinflammatory loop cycle ‐ 4‐signalling axes, may contribute the chronicity of this disease.