Resting‐state functional MRI distinguishes temporal lobe epilepsy subtypes

• DOI: 10.1111/epi.13456
• Publication Date: 2016-07-04T10:13:24Z
• Authors: Anny Reyes; Thomas Thesen; Xiuyuan Wang; Daniel Hahn; Daeil Yoo; Ruben Kuzniecky; Orrin Devinsky; Karen Blackmon
• Keywords: Hippocampal sclerosis

Summary Objective We assessed whether presurgical resting state functional magnetic resonance imaging (fMRI) provides information for distinguishing temporal lobe epilepsy (TLE) with mesial sclerosis (TLE‐MTS) from TLE without MTS (TLE‐noMTS). Methods Thirty‐four patients and 34 sex‐/age‐matched controls consented to a research protocol. status was confirmed by histologic evaluation of surgical tissue (TLE‐MTS = 16; TLE‐noMTS 18). The fractional amplitude low‐frequency fluctuations (fALFFs) in the blood oxygen level–dependent (BOLD) resting‐state fMRI signal, marker local metabolic demand at rest, averaged five regions interest (ROIs; hippocampus, amygdala, frontal, occipital, lobe), along corresponding volume cortical thickness estimates. ROIs were labeled ipsilateral or contralateral according seizure lateralization compared across TLE‐MTS, TLE‐noMTS, healthy (HCs). regressed on hippocampal fALFF test independent contributions. Results TLE‐MTS group had reduced amygdala hippocampus; whereas, marginally but not hippocampus. These results consistently obtained application global signal regression (GSR). Ipsilateral contributed 37% variance (p < 0.001) an additional 10% 0.021). Two cases accurately classified volume, three fALFF. At lobar level, (with GSR) bilateral frontal lobes context normal thickness. Significance This study indicates that complementary classification. Findings validate as measure regional brain integrity highlight value using multi‐modal provide diagnostic evaluations.