New stimulation procedures for language mapping in stereo‐EEG

• DOI: 10.1111/epi.17963
• Publication Date: 2024-04-06T12:54:02Z
• Authors: Belén Abarrategui; Veronica Pelliccia; Ginevra Giovannelli; Michele Nichelatti; Serena Valenzano; Ezequiel Mikulan; Andrea Pigorini; Martina Revay; Pina Scarpa; Laura Tassi
• Keywords: Basal (medicine); Brain mapping

Abstract Objective Cortical intracerebral electrical stimulation is an important tool for language mapping in the presurgical work‐up of patients with drug‐resistant focal epilepsy. Language stereo–electroencephalography (EEG) usually performed by high‐frequency stimulations (HFS: 50 Hz), whereas low‐frequency (LFS: 1 Hz) are considered useful primary cortices mapping. Little known literature about “intermediate” frequencies (IFS: 6–15 Hz). Our objective to explore clinical usefulness IFS and identify factors, beyond parameters, that impact Methods We studied 23 submitted stereo‐EEG evaluation. was anterior, posterior and/or basal region dominant hemisphere language. included all contact positions within these regions stimulated HFS (50 Hz, 5 s, 1–3 mA) (6‐15 15 mA). compared capability both methods induce a deficit without afterdischarges (ADs), we analyzed factors related examination, region, technique multivariate analysis. Results A total 211 (98 HFS, 113 IFS) 70 cortical sites anterior (84 stimulations), (137), (60) were included. induced more frequently deficits not associated AD (37.1% vs 25.7%, p = .0043), provoked diffuse (34.7% 15.0%, .001). Investigating multiple functions increased probability revealing (odds ratio [OR] 3.16, .0016), independently method. Significance valuable mapping, thereby improving inducing accompanied AD. The completeness examination affects sensitivity new potential other associative regions.