Identification of PTPN22,ST6GAL1 and JAZF1 as psoriasis risk genes demonstrates shared pathogenesis between psoriasis and diabetes

• DOI: 10.1111/exd.13393
• Publication Date: 2017-06-12T07:06:46Z
• Authors: Honglei Wang; Zhenzhen Wang; Parimi Leela Rani; Xi'an Fu; Wenjun Yu; Fangfang Bao; Gongqi Yu; Jianke Li; Lulu Li; Lele Sun; Zhenhua Yue; Qing Zhao; Qing Pan; Jing Cao; Chuan Wang; Xiaojun Chi; Yaru Wang; Qing Yang; Zihao Mi; Hong Liu; Furen Zhang
• Keywords: Pathogenesis; Genetic predisposition; PTPN22

The biological connections between psoriasis and diabetes have been suggested by epidemiological, immunological genetic studies. To identify additional shared susceptibility loci investigate pathogenesis these two diseases, we genotyped 89 reported in 4456 cases 6027 controls of Chinese population using the MassARRAY system from Sequenom. We discovered three significant associations at rs6679677 on 1p13.2 (P=6.15×10-5 , OR=5.07), rs16861329 3q27.3 (P=2.02×10-4 OR=0.87) rs849135 7p15.1 (P=6.59×10-9 OR=1.78), which PTPN22, ST6GAL1 JAZF1 as novel genes for population. Our findings implicated involvement T-cell receptor signalling pathway further confirmed diabetes.