GDNF neurotrophic factor signalling determines the fate of dermal fibroblasts in wound‐induced hair neogenesis and skin regeneration

• DOI: 10.1111/exd.14526
• Publication Date: 2022-01-12T15:17:34Z
• Authors: Neda Vishlaghi; Sandra Rieger; Vanessa McGaughey; Thomas S. Lisse
• Keywords: Neogenesis

Abstract We propose that GDNF, a glial cell line‐derived neurotrophic factor, can promote hair follicle neogenesis and skin regeneration after wounding by directing the fate of dermal fibroblasts. Our hypothesis is largely based on detailed GDNF receptor analysis during regenerative stages, as well induction receptors between pro‐regenerative spiny mouse (genus Acomys ) its less‐regenerative descendant, house ( Mus musculus ). To characterize GDNF‐target cells, we will conduct series lineage‐tracing experiments in conjunction with single‐cell RNA assay for transposase‐accessible chromatin sequencing experiments. The heterogenetic dynamics have yet to be fully defined, this research help advance fields medicine biology. Finally, believe stimulating signalling pathway fibroblasts from animals, such humans, regeneration, morphogenesis scarless wound healing.