Function of intestinal barrier protected by regulating the miR‐199a‐3p in ulcerative colitis: Modulation of IL‐23/IL‐17A axis

• DOI: 10.1111/fcp.12650
• Publication Date: 2021-01-21T19:01:36Z
• Authors: Huixia Zhang; Fangbin Zhang; Wei Li
• Keywords: Modulation (music); Barrier function

Ulcerative colitis is a chronic inflammatory bowel disorder, which having higher mortality rate. The present report evaluates the protective effect of miR-199a-3p oligomer for treatment (UC). was induced by administration dextran sulfate sodium [DSS (3%)] with drinking water duration one week in mice and treated same duration. Effect determined estimating body weight, blood stool length colon UC mice. Inflammatory cytokines, oxidative stress parameters Treg/Th17 ratio serum, intestinal spleen tissue mRNA expression TGFβ, Foxp3, RORγt STAT3 estimated Moreover, permeability intestine FITC-dextran serum junction protein data study suggest that ameliorates altered condition ulcerative There reduction level cytokines than group. enhanced Th17 attenuated In conclusion, barrier down regulating IL-17A/IL-23 axis.