Lymphotoxin α induces apoptosis, necroptosis and inflammatory signals with the same potency as tumour necrosis factor

• DOI: 10.1111/febs.12419
• Publication Date: 2013-07-02T09:09:44Z
• Authors: Nima Etemadi; Jessica K. Holien; Diep Chau; Grant Dewson; James M. Murphy; Warren S. Alexander; Michael W. Parker; John Silke; Ueli Nachbur
• Keywords: RIPK1; TRAF2; Mediator

Both of the TNF superfamily ligands, and LT α, can bind signal through TNFR 1 2, yet mice mutant for each have different phenotypes. Part this difference is because α but not activate Herpes Virus Entry Mediator also heterotrimerise with β to βR, which consistent similar phenotypes βR deficient mice. However, it has been reported that LTα 3 homotrimer signals differently than 1, unique roles in initiation exacerbation some inflammatory diseases. Our modeling / interface compared structure revealed differences could affect signalling by two ligands. To determine whether there were any functional ability induce 1‐dependent apoptosis or necroptosis, if requirements c IAP s Sharpin transmit signal, we cells respond . Contrary our hypothesis, unable discover response results imply reasons conservation are most likely due either differential regulation, form heterotrimers β. Structured digital abstract alpha physically interacts RIPK1 cIAP1 tandem affinity purification ( View interaction ) blue native page