Long non‐coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling

• DOI: 10.1111/febs.12737
• Publication Date: 2014-02-05T07:43:01Z
• Authors: Yu Fan; Bing Shen; Mingyue Tan; Xinyu Mu; Yan Qin; Fang Zhang; Yong Liu
• Keywords: Viability assay

Chemotherapy is a reasonable alternative to cystectomy in patients with invasive and advanced bladder cancer. However, cancer cells often develop drug resistance these therapies, ~ 50% of do not respond chemotherapy. Recent studies have shown that long non-coding RNA (lncRNA) involved the development chemoresistance. Here we investigated role urothelial cancer-associated 1 (UCA1) lncRNA cisplatin during chemotherapy for We showed cisplatin-based results up-regulation UCA1 expression Similarly, levels are increased cisplatin-resistant cells. Over-expression significantly increases cell viability treatment, whereas knockdown reduces treatment. inhibition also partially overcomes T24 Furthermore, positively regulates wingless-type MMTV integration site family member 6 (Wnt6) human lines. Wnt6 correlated vivo. Up-regulation activates Wnt signaling Wnt6-dependent manner. finally demonstrate by enhancing Wnt6, thus represents potential target overcome chemoresistance