Indolepropionic acid reduces obesity‐induced metabolic dysfunction through colonic barrier restoration mediated via tuft cell‐derived IL‐25

• DOI: 10.1111/febs.16470
• Publication Date: 2022-05-05T04:37:41Z
• Authors: Lu Chen; Yuxuan Yang; Siyu Sun; Yuan Xie; Cailong Pan; Maining Li; Chen Li; Yu Liu; Zhipeng Xu; Wentao Liu; Minjun Ji
• Keywords: Tuft

Previous studies have indicated that indolepropionic acid (IPA), derived from dietary tryptophan via gut microbiota conversion, is negatively correlated with type 2 diabetes mellitus and systemic low-grade inflammation. However, the effects of IPA administration on obesity, as well underlying mechanisms, remain unclear. In present study, we observed obesity leads to a dramatic reduction in levels both serum colonic mucosa, supplementation exerted beneficial weight, glucose lipid metabolism disorders. adipose tissue, treatment had no direct effect adipocyte differentiation, but it significantly ameliorated inflammation, thus preventing enlargement. Moreover, promoted integrity, increased expression tight junction proteins, downregulated inflammation; these were demonstrated poor relationship composition. Mechanistically, expansion tuft cell lineage secretion interleukin-25 vivo ex vivo, which contributes integrity barrier. This may partly depend free fatty receptor 3 pathway cells. Overall, our results demonstrate prevents development high-fat diet-induced metabolic disorders by restoring cell-interleukin-25-mediated barrier integrity; hence, could be potential agent for obesity.