Propensity for social interaction predicts nicotine‐reinforced behaviors in outbred rats

• DOI: 10.1111/gbb.12112
• Publication Date: 2013-11-30T13:08:48Z
• Authors: T. Wang; W. Han; B. Wang; Q. Jiang; L. C. Solberg‐Woods; A. A. Palmer; H. Chen
• Keywords: Self-administration

Social and genetic factors can influence smoking behavior. Using olfactogustatory stimuli as the sensory cue for intravenous nicotine self-administration (SA), we previously showed that social learning of contingent odor prevented rats from developing conditioned taste aversion allowed them to instead establish stable SA. We hypothesized influenced socially acquired A heterogeneous stock (HS; N/NIH) outbred was trained self-administer using protocol. Both male female HS SA, but females self-administered more than males. After extinction, context paired with in conjunction transmitted drug cues, sufficient cause reinstatement drug-seeking Wide variation both intake observed. multiple regression analysis, found measures interaction were significant predictors seeking males females. Furthermore, depression females, anxiety a predictor only response novelty In males, predicted reinstatement. Together, these data supported ideas genetically determined propensities emotional phenotypes are determinants nicotine-reinforced behavior, rat is suitable tool dissecting mechanisms may underlie between anxiety, smoking.