Association of metabolic syndrome and 25‐hydroxyvitamin D with cognitive impairment among elderly Koreans

• DOI: 10.1111/ggi.12826
• Publication Date: 2016-07-22T09:52:40Z
• Authors: Eun Young Lee; Su Jin Lee; Kyoung Min Kim; Young Mi Yun; Bo Mi Song; Jong Eun Kim; Hyeon Chang Kim; Yumie Rhee; Yoosik Youm; Chang Oh Kim
• Keywords: Male; Rural Population; 610; vitamin D; Comorbidity; elderly; Risk Assessment; metabolic syndrome; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; 616; Odds Ratio; Prevalence; Humans; Cognitive Dysfunction; Prospective Studies; Geriatric Assessment; cognitive impairment; Aged; Aged, 80 and over; Metabolic Syndrome; Analysis of Variance; Korea; Prognosis; Logistic Models; Female; Independent Living

Abstract Aim Metabolic syndrome and vitamin D deficiency are prevalent in older adults, considered risk factors for cognitive impairment. We investigated the combined effects of MetS serum 25‐hydroxyvitamin (25[OH]D) levels on function adults. Methods studied 2940 participants aged ≥65 years from Korean Urban Rural Elderly cohort study. was defined according to updated Adult Treatment Panel III criteria. Serum 25(OH)D were categorized into four groups: <25, 25–49, 50–74 ≥75 nmol/L. Cognitive assessed using Mini‐Mental State Examination. Results Participants with impairment had higher metabolic prevalence lower than those without In univariate analysis, both low associated These associations remained unchanged after adjusting potential confounders including age, sex, season education. addition, significantly increased odds (odds ratio 3.06, 95% CI 1.61–5.80) when compared no high 25(OH)D. Conclusions impairment, this synergistically A focus individuals might be helpful identify adults who at Geriatr Gerontol Int 2017; 17: 1069–1075 .