Effects of caffeine on intracranial pressure and pain perception in freely moving rats

• DOI: 10.1111/head.14634
• Publication Date: 2023-10-05T20:07:19Z
• Authors: Ida Marchen Egero...; Connar Stanley Ja...; Christina Kamp‐Je...; Rigmor H. Jensen; Sajedeh Eftekhari
• Keywords: Pain Perception

Caffeine, a non-selective adenosine receptor (AR) antagonist, is the most consumed psychostimulant in world. Caffeine has been suggested to regulate cerebrospinal fluid secretion and known both alleviate trigger headache; however, its effect on regulation of intracranial pressure (ICP) not known. Therefore, we aimed investigate effects caffeine ICP nociceptive responses.