Helicobacter pylori infection is associated with the co‐occurrence of bacteria in the oral cavity and the gastric mucosa

• DOI: 10.1111/hel.12786
• Publication Date: 2021-02-20T14:49:10Z
• Authors: Zhen‐Feng Wu; Kun Zou; Chun‐Jie Xiang; Zhao‐Jia Jin; Hai‐Hua Ding; Shuo Xu; Guan‐Nan Wu; Yao‐Hui Wang; Xiao‐Yu Wu; Che Chen; Xue‐Quan Yao; Jun‐Feng Zhang; Fu‐Kun Liu
• Keywords: Oral Microbiome; Dysbiosis; Pathogenic bacteria; Oral mucosa

Abstract Background Pathogens capable of impacting gastrointestinal tract tumor development are located in the oral cavity, but whether these bacteria able to colonize gastric mucosa cancer (GC) patients and Helicobacter pylori infection can influence this process remains be established. Methods Microbial 16S rDNA deep sequencing was conducted characterize present paired tongue coating samples 27 with superficial gastritis (SG) 11 GC patients. Results While overall composition microbiomes differed substantially, certain were both communities. The co‐occurrence between significantly SG Of 15 most abundant shared genera (the core bacteria), which associated differences microbiota mucosa, three enriched relative patients, whereas, 12 depleted patient samples. Furthermore, prevalence abundance also linked H . status, mucosal microbiome. Conclusions infections microbiome Ectopic colonization microbes may a primary driver ‐induced microbial dysbiosis GC.