Transmission ofHelicobacter pyloribetween a human and two dogs: A case report

• DOI: 10.1111/hel.12798
• Publication Date: 2021-04-05T12:49:00Z
• Authors: Sanae Kubota‐Aizawa; Yasuo Matsubara; Hideyuki Kanemoto; Hitomi Mimuro; Kazuyuki Uchida; James Chambers; Masaya Tsuboi; Koichi Ohno; Kenjiro Fukushima; Naoya Kato; Hiroshi Yotsuyanagi; Hajime Tsujimoto
• Keywords: 0303 health sciences; 03 medical and health sciences; Dogs; Helicobacter pylori; Animals; Humans; Female; Dog Diseases; Helicobacter Infections; 3. Good health

ABSTRACTBackgroundWhereas non‐Helicobacter pylorihelicobacters, which are frequently detected in the stomachs of dogs and cats as a source of zoonoses, have attracted considerable attention, the role of pets inH. pyloriepidemiology is unclear. In our previous study, anH. pyloriinfection was detected in the stomach of a dog (Dog 1). Here, we investigated theH. pyloriinfection status in the female offspring of Dog 1 (Dog 2) and its owner within the same household.Materials and MethodsBiopsy specimens were obtained from the dog's owner and tested forH. pylori. DNA from gastric biopsy samples of Dog 1, gastric fluid sediment of Dog 2, and bacteria from the stomach of the owner was obtained, andHelicobactergenus‐ and species‐specific PCRs were performed. Then, sequence analyses of the partial region of theureABgene were conducted.ResultsSamples from both dogs and the owner reacted positively in the genus‐specific PCR and negative in theHelicobacter felis‐,Helicobacter bizzozeronii‐, andHelicobacter heilmanniisensu stricto‐specific PCRs. All three samples also reacted positively in theH. pylori‐specific PCR. Sequences of the partialureABgene from all subjects were identical.ConclusionsThe results suggested that the two dogs and their owner were infected with an identicalH. pyloristrain. This report is the first to demonstrate thatH. pylorican be transmitted between humans and dogs. Further studies are required to investigate the risk factors for the transmission ofH. pyloribetween humans and dogs from the perspective of preventive epidemiology.