Impact of body fat accumulation on metabolic dysfunction‐associated fatty liver disease and nonalcoholic fatty liver disease in Japanese male young adults

• DOI: 10.1111/hepr.13906
• Publication Date: 2023-05-05T06:00:10Z
• Authors: Takao Miwa; Cathelencia Franc...; Satoko Tajirika; Tatsunori Hanai; Nanako Imamura; Miho Adachi; Ryo Horita; Lynette J Menezes; Takumi Kawaguchi; Masahito Shimizu; Mayumi Yamamoto
• Keywords: 2. Zero hunger; 3. Good health

Nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated (MAFLD) are global concerns. The aim of this study was to reveal the relationship between body composition NAFLD MAFLD in male young adults.We recruited 335 graduate students from Gifu University who underwent a health checkup April 2022. diagnosis based on data ultrasonography. Muscle fat mass were measured using bioelectrical impedance analysis demonstrated as skeletal muscle index (FMI), respectively. We assessed factors associated with logistic regression, decision tree, random forest analyses.The median age participants 22 years, 9% overweight or obese (body ≥25 kg/m2 ), 8% had MAFLD, 16% NAFLD. In multivariate regression analysis, FMI independently (odds ratio [OR], 1.49; 95% confidence interval [CI], 1.26-1.75; p < 0.001) (OR, 1.93; CI, 1.51-2.46; 0.001). tree analyses revealed that strongest classifier for FMI. Additional among nonobese individuals also showed strong FMI, NAFLD, MAFLD.Our accumulation plays key role development adults, even individuals. results could shed new light pathophysiology adults.