Hypoacetylation of acetyl‐histone H3 (H3K9ac) as marker of poor prognosis in oral cancer

• DOI: 10.1111/his.13218
• Publication Date: 2017-03-23T01:55:43Z
• Authors: Liana P Webber; Vivian P Wagner; Marina Curra; Pablo A Vargas; Luise Meurer; Vinícius C Carrard; Cristiane H Squarize; Rogério M Castilho; Manoela D Martins
• Keywords: Adult; Male; Epithelial-Mesenchymal Transition; Acetylation; Kaplan-Meier Estimate; Middle Aged; Prognosis; 3. Good health; Histones; 03 medical and health sciences; Cell Transformation, Neoplastic; 0302 clinical medicine; Biomarkers, Tumor; Carcinoma, Squamous Cell; Humans; Female; Mouth Neoplasms; Leukoplakia, Oral; Aged

Epigenetics refers to changes in cell characteristics that occur independently of modifications the DNA sequence. Oral carcinogenesis is influenced by epigenetic mechanisms, including histones, which are proteins support chromatin remodelling for dynamic regulation gene expression and silencing. The dysregulation histone acetylation can lead uncontrolled activity different genes, thereby triggering events associated with malignant transformation. aim this study was analyse acetyl-histone H3 at lys9 (H3K9ac) oral leucoplakia (OL) squamous carcinoma (OSCC) addition its association proliferation, epithelial-mesenchymal transition (EMT) clinical-pathological findings.Samples normal mucosa (NOM), OL OSCC were submitted immunohistochemical analysis using anti-H3K9ac, Ki67 vimentin. Slides quantitative regarding percentage positive cells. presented less H3K9ac comparison (P < 0.01), whereas vimentin levels increased from 0.001 P = 0.03, respectively). patients poor prognosis had 0.04). Kaplan-Meier cumulative survival curves also revealed lower rates 0.01).The present findings suggest during process along an increase proliferation EMT. results demonstrate may be a useful novel prognostic marker OSCC.