Primary effusion lymphoma in Taiwan shows two distinctive clinicopathological subtypes with rare human immunodeficiency virus association

• DOI: 10.1111/his.13449
• Publication Date: 2017-12-05T15:12:41Z
• Authors: Bo‐Jung Chen; Ran‐Ching Wang; Chung‐Han Ho; Chang‐Tsu Yuan; Wan‐Ting Huang; Sheau‐Fang Yang; Pin‐Pen Hsieh; Yun‐Chih Yung; Shih‐Yao Lin; Chen‐Fang Hsu; Ying‐Zhen Su; Chun‐Chi Kuo; Shih‐Sung Chuang
• Keywords: Plasmablastic lymphoma; Primary effusion lymphoma; Immunophenotyping; BCL6; Univariate analysis

To investigate the clinicopathological and molecular features of primary effusion lymphoma (PEL) in Taiwan association with human immunodeficiency virus (HIV), herpesvirus 8 (HHV8) Epstein-Barr (EBV).We investigated retrospectively 26 cases a median age 76.5. Only one (4%) patient was infected HIV. Cytologically, all cells revealed typical immunoblastic to plasmablastic morphology. Immunohistochemically, HHV8 positive eight (32%) tumours negative 17 (68%) cases. All 23 tested examined were non-germinal-centre B cell phenotype. MYC proto-oncogene (MYC) encoding mRNA (EBER) 43% (nine 21) 17% (four 23) cases, respectively. Immunoglobulin heavy chain (IGH), (BCL)2, BCL6 rearranged 71%, 11%, 12% 18% By univariate analysis, overall survival (OS) associated statistically expression (P = 0.012) BCL2 rearrangement 0.035), but not others. multivariate no factor significant. Compared HHV8-negative HHV8-positive mainly immunophenotype expressing CD30 CD138, less frequent pan-B markers.Apart from phenotypical difference, our neoplasms distinct group. Literature review 256 including that more frequently HIV EBV infection, rare rearrangement, poorer prognosis than We propose name as 'classical' or 'type I PEL' II PEL', stressing similarities distinctive between these two groups.