The value of serum thyroglobulin alteration after ultrasonography‐guided fine‐needle biopsy of suspicious cervical lymph nodes in the diagnosis of metastasis in patients with differentiated thyroid cancer

• DOI: 10.1111/ijcp.14218
• Publication Date: 2021-04-18T18:55:31Z
• Authors: Fatma Dilek Dellal; Cevdet Aydin; Abbas Ali Tam; Sevgul Faki; Afra Alkan; Sefika Burcak Polat; Ahmet Dirikoc; Oya Topaloglu; Reyhan Ersoy; Bekir Cakir
• Keywords: Thyroglobulin; Echogenicity

Background It is known that serum thyroglobulin (TG) can increase after fine-needle biopsy of thyroid nodules. We aimed to determine whether TG increased ultrasonography (US)-guided fine needle capillary (FNC) suspicious cervical lymph nodes (LNs) in thyroidectomised patients and investigate the possible association between change cytology results. Material Methods Data 188 who underwent FNC LNs were retrospectively evaluated. Demographical, laboratory features noted. levels before (TGb-FNC), (TGa-FNC), TGa-FNC/TGb-FNC ratio number with determined. Patients grouped as benign, nondiagnostic, for malignancy malignant according cytological Results TGa-FNC, TGb-FNC/TGa-FNC rate significantly higher group than other groups (P < .001). The optimal cut-off level was predictive 7.6% a sensitivity 73.7% specificity 85.2%. not associated age, sex, Thyroid-stimulating hormone (TSH) level, anti-TG positivity US while lower received radioactive iodine (RAI) treatment. Among 31 positive anti-TG, TGb-FNC/TGa-FNC, compared benign nondiagnostic groups. Conclusions Serum increment all results both study sub-group patients. Increase might be an additional tool determining LN metastasis.