Expression and significance of phosphodiesterase 4B gene in peripheral blood of patients with oral lichen planus

• DOI: 10.1111/ijd.14203
• Publication Date: 2018-09-19T12:20:05Z
• Authors: Chen Wang; Shan Li; Chen Shen; Jing Shan; Yuan Fan
• Keywords: Adult; Male; Psychiatric Status Rating Scales; Synaptogyrins; Depression; Gene Expression; Nuclear Proteins; Nerve Tissue Proteins; Anxiety; Middle Aged; Cyclic Nucleotide Phosphodiesterases, Type 4; 3. Good health; Cytoskeletal Proteins; 03 medical and health sciences; 0302 clinical medicine; Case-Control Studies; Humans; Female; RNA, Messenger; RGS Proteins; Lichen Planus, Oral

Background The pathogenesis of oral lichen planus (OLP) may be related to mental factors. In this study, we investigated the molecular mechanism factors in development OLP. Methods normal control group and OLP patients were tested evaluated by Zung self-rating anxiety scale depression scale. Secondly, Agilent human LncRNA chip technology was used detect differential genes total RNA patients, screen out differentially expressed depression. Thirdly, verified at gene level protein level, respectively. Results showed that tendency is significantly higher than controls, but there no significant difference between erosion form reticular group; duration negative correlations degree Microarray analysis four (PDE4B, RGS2, SYNGR1, SYNE1) patients; real-time qPCR confirmed expression PDE4B mRNA lower peripheral blood (P < 0.001). SYNE1 0.05, P 0.05). Wes automatic western blot 0.01). Conclusion play a role