Release of dipeptidyl peptidase IV inhibitory peptides from salmon (Salmosalar) skin collagen based on digestion–intestinal absorption invitro

• DOI: 10.1111/ijfs.14977
• Publication Date: 2021-01-23T17:43:09Z
• Authors: Jin Ritian; Xiangyu Teng; Minhe Liao; Ligang Zhang; Zikai Wei; Ran Meng; Ning Liu
• Keywords: Dipeptidyl peptidase; Digestion

Summary Inhibition of dipeptidyl peptidase IV (DPP‐IV) was considered to be a crucial target for type 2 diabetes, and food‐derived peptides were superior source DPP‐IV inhibitory peptides. The purpose this investigation identify from salmon skin collagen using simulated digestion combined with Caco‐2 cell monolayer membrane model. analysis in silico showed that TKLPAVF YLNF potential Determination the inhibition activity IC 50 values TKLPVAF 242.10 ± 3.40 146.90 4.40 µ m , respectively. Molecular docking results seven hydrogen bonds formed between key residues DPP‐IV. may novel peptide. In addition, could transported by intact, apparent permeability coefficient value (3.54 0.34) × 10 ‐6 cm s −1 at 5 .