Burden of Stroke in Italy: An Economic Model Highlights Savings Arising from Reduced Disability following Thrombolysis

• DOI: 10.1111/ijs.12481
• Publication Date: 2015-04-09T01:09:48Z
• Authors: M. Chiumente; M. M. Gianino; D. Minniti; T. J. Mattei; B. Spass; K. M. Kamal; D. E. Zimmerman; A. Muca; E. Luda
• Keywords: Stroke; Clinical neurology

Background The consequences of stroke must be assessed not only in terms incidence and mortality rates, but also disability, which may persist long after the acute phase. Thrombolysis, if timely administered, can effectively reduce post-stroke disability. Aims economic model presented herein aims to evaluate, eligible patients, effects alteplase on disability related costs over three-years. Methods analysis was developed basis four key components: clinical outcomes from international trials, extracted cost illness studies, regulatory data national agencies, epidemiological data. A population-level estimated difference between patients treated with standard care versus those receiving thrombolytic therapy within 4×5 h ischemic stroke. covered 36 months discharge. Results Reduced were observed compared (control). overall savings ¢2330×15 per average patient: ¢1445×81 during first 18 months, ¢362×25 24 ¢522×09 24–36 period. 3174 Italian 2013 ¢7 395 907 Conclusion Our study reveals that performing improves care. This is useful for decision makers, both outside context, as a tool assess cost-effectiveness thrombolysis short- long-term