Gemcitabine‐induced thrombotic microangiopathy

• DOI: 10.1111/imj.12261
• Publication Date: 2013-11-15T07:40:16Z
• Authors: J. Richmond; P. Gilbar; E. Abro
• Keywords: Thrombotic microangiopathy; Microangiopathy

Thrombotic microangiopathy (TMA) is a microvascular occlusive disorder characterised by platelet aggregation, thrombocytopenia and end-organ damage. It commonly idiopathic, although several drug classes, including cytotoxic chemotherapy, have been implicated. Several of cases gemcitabine-induced TMA documented with incidence likely to increase the escalating use gemcitabine. We report two patients who developed while on gemcitabine chemotherapy.