An alternative mode ofCD43 signal transduction activates pro‐survival pathways of T lymphocytes

• DOI: 10.1111/imm.12670
• Publication Date: 2016-09-08T15:03:21Z
• Authors: Maria Elena Bravo...; Rosario Vera‐Estr...; Bronwyn J. Barkla; Cecilia Martínez‐...; Angel Flores‐Alca...; Jose Pablo Ocelot...; Gustavo Pedraza‐Alva; Yvonne Rosenstein
• Keywords: PKM2

Summary CD 43 is one of the most abundant co‐stimulatory molecules on a T‐cell surface; it transduces activation signals through its cytoplasmic domain, contributing to modulation outcome responses. The aim this study was uncover new signalling pathways regulated by sialomucin. Analysis changes in protein abundance allowed us identify pyruvate kinase isozyme M2 ( PKM 2), an enzyme glycolytic pathway, as element potentially participating cascade resulting from engagement and receptor TCR ). We found that activity not significantly increased response + co‐stimulation, but 2 tyrosine phosphorylated, suggesting performing moonlight functions. report phosphorylation both Y 105 705 signal transducer activator transcription 3 induced mitogen‐activated 5/extracellular signal‐regulated 5 MEK 5/ ERK 5) pathway. cAMP binding CREB ) were activated, c‐Myc nuclear factor‐ κ B (p65) localization, well Bad phosphorylation, augmented. Consistent with this, expression human murine hybridoma favoured cell survival. Altogether, our data highlight novel for molecule T lymphocytes, underscore role promoting survival non‐glycolytic functions metabolic enzymes.