LncRNA00492 is required for marginal zone B‐cell development

• DOI: 10.1111/imm.13408
• Publication Date: 2021-08-26T08:31:17Z
• Authors: Faming Wang; Dongya Cui; Qingyun Zhang; Yingying Shao; Baijiao Zheng; Liling Chen; Yao Luo; Liudi Yuan; Demin Wang
• Keywords: Corepressor

B-cell development undergoes a series of steps from the bone marrow to secondary lymphoid organs. A defect in can lead immunodeficiency or malignant disorders, such as leukaemia lymphoma. Long non-coding RNAs have been reported act important regulators many pathological processes. However, very little is known regarding role lncRNAs during and regulation their expression. In this study, we explored expression lncRNA Gme00492 development. We observed that lnc00492 was highly expressed primarily nucleus. Lnc00492-deficient mice had fewer marginal zone B cells spleen, likely due developmental block. Importantly, interacts with CTBP1 targets it for ubiquitination degradation development, whereas transcriptional corepressor factor plays critical Notch2 signalling. Thus, identified novel regulatory axis between cells, suggesting essential