The relationship between peripheral immune response and disease severity in SARS‐CoV‐2‐infected subjects: A cross‐sectional study

• DOI: 10.1111/imm.13457
• Publication Date: 2022-02-11T04:35:14Z
• Authors: Laura Otto Walter; Chandra Chiappin ...; Íris Mattos Santo...; Heloisa Zorzi Costa; Rafaela Gartner; Isabel Werle; Eduarda Talita Br...; Julia Salvan da Rosa; Mariano Felisberto; Iara Fabricia Kre...; Ivete Ioshiko Mas...; Patrícia de Almei...; Magali Chaves Luiz; Ana Carolina Rabe...; Eduardo Monguilho...; Maria Cláudia San...
• Keywords: Neutrophilia; Immunosuppression

Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by severe acute syndrome coronavirus 2 (SARS-CoV-2) and marked an intense inflammatory response immune dysregulation in the most cases. In order to better clarify relationship between peripheral system changes severity of COVID-19, this study aimed evaluate frequencies absolute numbers subsets neutrophils, monocytes, dendritic cells (DCs), addition quantifying levels mediators. One hundred fifty-seven COVID-19 patients were stratified into mild, moderate, severe, critical categories. The cellular components circulating cytokines assessed flow cytometry. Nitric oxide (NOx) myeloperoxidase (MPO) measured colourimetric tests. presented neutrophilia, with signs emergency myelopoiesis. Alterations monocytic component observed moderate illness, increase classical monocytes reduction nonclassical expression HLA-DR all subtypes indicating immunosuppression. DCs, especially plasmacytoid also showed large patients. MPO, interleukin (IL)-12, IL-6, IL-10, IL-8, accompanied IL-17A NOx. IL-10 ≥14 pg/ml strongly related worst outcome, sensitivity 78·3% specificity 79·1%. results indicate presence systemic effects induced which appear be pathophysiology disease, highlighting potential as possible prognostic biomarker for COVID-19.