T cell maturation is significantly affected by SARS‐CoV‐2 infection

• DOI: 10.1111/imm.13635
• Publication Date: 2023-03-01T06:24:27Z
• Authors: Laura Otto Walter; Chandra Chiappin ...; Íris Mattos Santo...; Heloisa Zorzi Costa; Rafaela Gartner; Isabel Werle; Eduarda Talita Br...; Julia Salvan da Rosa; Tainá Larissa Lub...; Mariano Felisberto; Iara Fabricia Kre...; Ivete Ioshiko Mas...; Patrícia de Almei...; Magali Chaves Luiz; Ana Carolina Rabe...; Eduardo Monguilho...; Maria Cláudia San...
• Keywords: CD4-Positive T-Lymphocytes; SARS-CoV-2; Humans; COVID-19; Cell Differentiation; CD8-Positive T-Lymphocytes; 3. Good health

Abstract Coronavirus disease 2019 (COVID‐19) is a respiratory tract infection caused by the new severe acute syndrome coronavirus 2 (SARS‐CoV‐2). An adequate T cell response essential not only for fighting but also creation of immune memory. Thus, present study aims to evaluate cells patients with moderate, and critical COVID‐19 at time illness months after diagnosis observe whether changes in this compartment persist. In study, 166 were stratified into moderate/severe categories. The maturation activation evaluated through flow cytometry. addition, Treg analysed. Until 15 days diagnosis, presented reduction absolute relative lymphocyte counts. After months, patients, counts returned similar level as that control group. convalescent who had illness, values increased considerably. Patients active did show differentiation cells. Nonetheless, showed significant increase CD4 + EMRA (CD45RA effector memory) lymphocytes. Furthermore, delayed reduced CD8 suppressor even diagnosis. A was observed, their numbers healthy controls patients. results demonstrate have these great phenotype.