KP‐103, a Novel Triazole Derivative, Is Effective in Preventing Relapse and Successfully Treating Experimental Interdigital Tinea Pedis and Tinea Corporis in Guinea Pigs

• DOI: 10.1111/j.1348-0421.2002.tb02716.x
• Publication Date: 2013-11-14T15:36:55Z
• Authors: Yoshiyuki Tatsumi; Mamoru Yokoo; Tadashi Arika; Hideyo Yamaguchi
• Keywords: Tinea Capitis

The therapeutic efficacy of KP-103, a triazole derivative, for 10 guinea pigs with interdigital tinea pedis or corporis was investigated. Topical KP-103 solution (0.25 to 1%) dose-dependently effective in treating both dermatophytoses. A 1% KP-103-treatment rendered all infected skins culture-negative on day-2 posttreatment. high negative-culture rate obtained solutions butenafine and lanoconazole but not neticonazole solution. follow up study performed day-30 day-9 posttreatment demonstrated that the relapse rates KP-103-treated animals those were 20 30%, respectively, these values same as butenafine-treated animals, lower than lanoconazole-treated (55 80%, respectively). When single dose applied back skin 48 hr before fungal inoculation, 9 protected from dermatophytosis, suggesting active is retained tissue at least after dosing. Moreover, it suggested retains activity horny layer because its keratin-affinity. effectiveness against dermatophytoses may be due favorable pharmacokinetic properties tissues, together potent antifungal activity.