Antigen 85A and mycobacterial DNA‐binding protein 1 are targets of immunoglobulin G in individuals with past tuberculosis

• DOI: 10.1111/j.1348-0421.2012.12005.x
• Publication Date: 2012-11-16T14:45:30Z
• Authors: Mayuko Osada‐Oka; Yoshitaka Tateishi; Yukio Hirayama; Yuriko Ozeki; Mamiko Niki; Seigo Kitada; Ryoji Maekura; Kunio Tsujimura; Yukio Koide; Naoya Ohara; Taro Yamamoto; Kazuo Kobayashi; Sohkichi Matsumoto
• Keywords: Adult; Male; 0301 basic medicine; Antigens, Bacterial; Mycobacterium tuberculosis; Middle Aged; Prognosis; Antibodies, Bacterial; Immunohistochemistry; 3. Good health; DNA-Binding Proteins; Young Adult; 03 medical and health sciences; Bacterial Proteins; Latent Tuberculosis; Immunoglobulin G; Asymptomatic Diseases; Humans; Tuberculosis; Female; Acyltransferases; Aged

Development of accurate methods for predicting progression tuberculosis (TB) from the latent state is recognized as vitally important in controlling TB, because a majority cases develop infections. Past TB that has never been treated higher risk progressing than does Mycobacterium infection patients who have previously received treatment. Antibody responses against 23 kinds M. proteins individuals with past had not medicated were evaluated. These significantly concentrations antibodies Antigen 85A and mycobacterial DNA-binding protein 1 (MDP1) did those active uninfected controls. In addition, immunohistochemistry revealed colocalization tubercle bacilli, antigen 85 MDP1 inside tuberculous granuloma lesions an asymptomatic subject, showing expresses both MDP1. Our study suggests potential usefulness measuring antibody to assessing progression.