Weather conditions and daylight-mediated photodynamic therapy: protoporphyrin IX-weighted daylight doses measured in six geographical locations

• DOI: 10.1111/j.1365-2133.2012.11200.x
• Publication Date: 2012-08-04T15:05:27Z
• Authors: S.R. Wiegell; S. Fabricius; J. Heydenreich; C.D. Enk; S. Rosso; W. Bäumler; B.T. Baldursson; H.C. Wulf
• Keywords: Daylight; Protoporphyrin IX; Sunlight; Actinic Keratoses

Photodynamic therapy (PDT) is an attractive for nonmelanoma skin cancers and actinic keratoses (AKs). Daylight-mediated methyl aminolaevulinate PDT (daylight-PDT) a simple painless treatment procedure PDT. All daylight-PDT studies have been performed in the Nordic countries. To be able to apply these results other parts of world we compare daily protoporphyrin IX (PpIX) light dose countries with PpIX doses found calculate where when AKs was possible six different geographical locations using ground stations measuring PpIX-weighted daylight doses. were measured dosimeter customer-specific photodiode detector sensitivity that mimics absorption spectrum measures 'PpIX doses'. The dosimeters built into placed from July December 2008. Temperature data each location obtained internet. maximal ultraviolet (UV) index Copenhagen period dosimeters. If should above 8Jcm(-2) maximum temperature day at least 10°C, it treat patients on nearly all days until middle September Reykjavik Oslo, last week October Regensburg, November Turin year Israel. Where perform depends outdoor temperature. influenced by (latitude), weather condition time year. UV not more suitable than predict if intensity would sufficient daylight-PDT.