Occurrence of disseminated Intravascular coagulation (DIC) in active systemic anaphylaxis: role of platelet-activating factor

• DOI: 10.1111/j.1365-2249.1995.tb03711.x
• Publication Date: 2010-07-27T10:03:39Z
• Authors: I H CHOI; T Y HA; D G LEE; J S PARK; J H LEE; Y M PARK; H K LEE
• Keywords: Platelet-activating factor

SUMMARY The possible occurrence of DIC in active systemic anaphylaxis was investigated mice. Induction resulted the development symptoms such as thrombo-cytopenia, prolongation prothrombin time, hypofibrinogaemia, and elevated level fibrinogen/fibrin degradation products. In addition, histological examinations, massive congestion cellular infiltration pulmonary interstitia, considerable haemorrhage renal medullae were observed. All these changes nearly completely prevented by pretreatment with platelet-activating factor (PAF) antagonist (BN 50739). Moreover, same haematological morphological produced a bolus injection PAF. These data strongly suggest that occurs PAF plays pivotal role anaphylaxis.