The retinoblastoma protein/p16INK4A pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma

• DOI: 10.1111/j.1365-2559.2011.03762.x
• Publication Date: 2011-02-16T18:02:30Z
• Authors: Elzbieta Stankiewicz; David M Prowse; Elena Ktori; Jack Cuzick; Laurence Ambroisine; Xiaoxi Zhang; Sakunthala Kudahetti; Nicholas Watkin; Catherine Corbishley; Daniel M Berney
• Keywords: Retinoblastoma; Retinoblastoma protein; Pathogenesis

Stankiewicz E, Prowse D M, Ktori Cuzick J, Ambroisine L, Zhang X, Kudahetti S, Watkin N, Corbishley C & Berney M (2011) Histopathology 58 , 433–439 The retinoblastoma protein/p16 INK4A pathway but not p53 is disrupted by human papillomavirus in penile squamous cell carcinoma Aims: pathogenesis of (PSCC) well understood. Human (HPV) may be involved carcinogenesis, few studies have compared cell‐cycle protein expression HPV positive and negative cancers. aim was to determine the extent infection different histological subtypes PSCC its impact on key proteins: p53, p21, p16 (RB) protein. Methods results: One hundred forty‐eight samples were examined immunohistochemically for RB, p21 expression. two cases typed PCR. DNA detected 56% tumours, with HPV16 present 81%. Basaloid tumours related strongly (10 13), while verrucous (three 13). Fifty‐nine per cent (38 64) usual type SCCs had infection. RB correlated negatively ( P < 0.0001) = 0.0002) positively did correlate Conclusions: more than half cancers it responsible disruption. However, no link between immunodetection found. Only basaloid usual‐type PSSCs infection, confirming possible separate aetiologies those tumours.