TLR2 and TLR4 expression in peripheral blood mononuclear cells of patients with chronic cystic echinococcosis and its relationship with IL‐10

• DOI: 10.1111/j.1365-3024.2011.01335.x
• Publication Date: 2011-09-19T09:28:29Z
• Authors: J.‐Y. SHAN; W.‐Z. JI; H.‐T. LI; T. TUXUN; R.‐Y. LIN; H. WEN
• Keywords: Cystic echinococcosis

This study aims at relating Toll-like receptors (TLR) and human systemic cytokines in patients with chronic cystic echinococcosis (CE). By real-time fluorescent quantitative reverse-transcription polymerase chain reaction, we measured the expression level of TLR2 TLR4 mRNA peripheral blood mononuclear cells (PBMCs), using ELISA, detected IFN-γ, IL-12p70, IL-10, IL-4 IL-17A from 34 CE cases (four biliary leakage; four secondary location including three lung one bone) 22 healthy controls (HC). were significantly higher group (P<0·05); levels serum IL-12p70 than those (P<0·05). There no differences IFN-γ between HC (P>0·05). In CE, positive correlations noted as well IL-10. Our findings supported hypothesis that during infection, altered TLR might be involved cytokine modulation, which allowed parasite to escape host immunosurveillance promoted infection.