Tγδ Cells and their Subsets in Blood and Synovial Tissue from Rheumatoid Arthritis Patients

• DOI: 10.1111/j.1365-3083.1990.tb03200.x
• Publication Date: 2006-06-30T22:19:34Z
• Authors: M. D. SMITH; B. BRÖKER; L MORETTA; E. CICCONE; C. E. GROSSI; J. C. W. EDWARDS; F. YÜKSEL; B. COLACO; C. WORMAN; L. MACKENZIE; R. KINNE; G. WESELOH; K. GLÜCKERT; P. M. LYDYARD
• Keywords: Adult; 0301 basic medicine; T-Lymphocytes; Synovial Membrane; Receptors, Antigen, T-Cell; Antibodies, Monoclonal; Receptors, Antigen, T-Cell, gamma-delta; Middle Aged; 3. Good health; Arthritis, Rheumatoid; Leukocyte Count; 03 medical and health sciences; T-Lymphocyte Subsets; Humans; Aged

We have examined the frequencies of Tγδ cells in blood, synovial fluids, and membranes patients with rheumatoid arthritis (RA) blood from age‐matched controls Immunocyto‐chemical immunohistochemical techniques were used monoclonal antibodies BB3 A13 to define a major minor subset respectively. Together, these identify majority (if not all) peripheral cells. Significantly lower levels found RA compared controls, whilst higher but significant numbers fluids or paired samples Scattered only some A distribution similar Analysis two different ‐cell subsets indicated ratio about 5:1 control blood. However, this was less than 1:1 membranes. The migratory nature + could account for their predominance sites possible pathological significance fluid is discussed.