Autoimmune diseases in patients with pemphigus and their first‐degree relatives

• DOI: 10.1111/j.1365-4632.2010.04818.x
• Publication Date: 2011-06-25T22:04:28Z
• Authors: Yael A. Leshem; Varda Katzenelson; Gil Yosipovitch; Michael David; Daniel Mimouni
• Keywords: Pemphigus vulgaris; First-degree relatives

Abstract Background Pemphigus is an autoimmune blistering disease affecting the skin and mucosa, which mostly in anecdotal reports has been associated with several diseases. Objective The aim of this study was to assess frequency diseases a large group patients pemphigus their first‐degree relatives. Methods One hundred ten were interviewed for existence various Patients’ sera examined presence autoantibodies. 969 relatives assessed via questionnaires. Results Seven 110 (6.3%) had concurrent diseases, including four (3.6%) thyroid three (2.7%) rheumatoid arthritis. Ten (1.03%) disease, (0.31%) arthritis, type 1 diabetes mellitus. patient’s statistically significant higher prevalence arthritis than ( P = 0.046 0.016 respectively). Conclusions Patients seem have rate both general population own Further studies comparing healthy controls are needed stratify risk factors developing other define guidelines regarding diagnosis treatment coexistent disorders.