PRECLINICAL STUDY: Chronic deep brain stimulation in the rat nucleus accumbens and its effect on morphine reinforcement

• DOI: 10.1111/j.1369-1600.2007.00088.x
• Publication Date: 2008-02-04T11:48:11Z
• Authors: Hong‐Yu Liu; Jie Jin; Jing‐Shi Tang; Wei‐Xin Sun; Hong Jia; Xin‐Ping Yang; Jian‐Mei Cui; Chen‐Guang Wang
• Keywords: Conditioned place preference

ABSTRACT In order to explore a novel method for the treatment of drug abuse, we evaluated effect chronic deep brain stimulation (DBS) rat nucleus accumbens (NAc) on morphine reinforcement, using DBS apparatus and an implant developed. Thirty‐two adult rats weighing 240–260 g were divided into three groups, which included group ( n = 10, administration surgery, DBS), sham 12, surgery morphine) control physiological saline). The electrode was stereotaxically implanted core unilateral NAc connected implantable pulse generator. Then, they fixed skull. One week later, in each intraperitoneally injected with at increasing dose (10–60 mg/kg) once daily. administered 130‐Hz high‐frequency (HFS) A 900‐second conditioned place preference (CPP) paradigm used determining electrical reinforcement rats. data showed that 7–10 days score significantly lower than group. results suggest HFS can block CPP induced by attenuate reinforcement.