Association ofOPRD1polymorphisms with heroin dependence in a large case-control series

• DOI: 10.1111/j.1369-1600.2012.00445.x
• Publication Date: 2012-04-13T19:58:32Z
• Authors: Elliot C. Nelson; Michael T. Lynskey; Andrew C. Heath; Naomi Wray; Arpana Agrawal; Fiona L. Shand; Anjali K. Henders; Leanne Wallace; Alexandre A. Todorov; Andrew J. Schrage; Pamela A. F. Madden; Louisa Degenhardt; Nicholas G. Martin; Grant W. Montgomery
• Keywords: Linkage Disequilibrium; SNP

Genes encoding the opioid receptors (OPRM1, OPRD1 and OPRK1) are obvious candidates for involvement in risk heroin dependence. Prior association studies commonly had samples of modest size, included limited single nucleotide polymorphism (SNP) coverage these genes yielded inconsistent results. Participants current investigation 1459 heroin-dependent cases ascertained from maintenance clinics New South Wales, Australia, 1495 unrelated individuals selected an Australian sample twins siblings as not meeting DSM-IV criteria lifetime alcohol or illicit drug dependence (non-dependent controls) 531 controls economically disadvantaged neighborhoods proximity to clinics. A total 136 OPRM1, OPRK1 SNPs were genotyped this sample. After controlling admixture with principal components analysis, our comparison non-dependent found four fairly high linkage disequilibrium which adjusted P values remained significant (e.g. rs2236857; OR 1.25; = 2.95 × 10−4) replicating a previously reported association. post hoc analysis revealed that two SNP (rs2236857 rs581111) GA haplotype is associated greater (OR 1.68; 1.41 10−5). No OPRM1 reached more than nominal significance. Comparisons neighborhood only Our results replicate prior report providing strong evidence implicating and, particular, liability Support was similar involving either SNPs.