Influence of prolonged cold ischemia in renal transplantation

• DOI: 10.1111/j.1399-0012.2011.01510.x
• Publication Date: 2011-09-15T16:41:54Z
• Authors: J. Adam van der V...; Michiel C. Warlé; C. L. Sarah Cheung; Steven Teerenstra; Andries J. Hoitsma
• Keywords: Warm ischemia; Cold ischemia

To determine to what extent current cold ischemia times (CITs) affect the results of renal transplantation in Netherlands.Retrospective survey Dutch Organ Transplant Registry concerning transplants from deceased donors between 1990 and 2007.A total 6322 recipients were identified, whom 5306 received a kidney heartbeating (HBD) 1016 after cardiac death (DCD). Mean CIT was 24.0 ± 7.9 h HBD 21.6 6.7 DCD. The percentage delayed graft function (DGF) 12.3 50.4, respectively (p < 0.001). Primary non-function (PNF) occurred in, respectively, 1.7% 5.0% Serum creatinine three months 166 μM 213 DCD Five-yr survival 79.5% 78.3%, = ns). In multivariate analysis, proved be an independent risk factor for DGF PNF. Shorter associated with better both groups hazard ratio 1.024 (1.011-1.037, 95% CI)/h. <20 benefit 3% five yr <16 10% DCD.Longer CITs are occurrence DGF, PNF decreased Netherlands.