Effects of Positive End‐Expiratory Pressure on Renal Function

• DOI: 10.1111/j.1399-6576.1978.tb01331.x
• Publication Date: 2009-01-01T09:14:02Z
• Authors: P.‐O. Järnberg; E. Dominguez de V...; J. Eklund; P.‐O. Granberg
• Keywords: Positive End-Expiratory Pressure; Free water clearance; Renal physiology

The effects were studied of positive end‐expiratory pressure (PEEP) on renal function in eight patients with acute respiratory failure, requiring mechanical ventilation. On application PEEP+ 10 cmH 2 O, central venous increased, systolic blood decreased, urine flow and PAH‐clearance reduced, while inulin clearance remained stable. There was a marked increase fractional sodium reabsorption concurrent decrease osmolal excretion. Fractional free‐water the ratio Uo sm /Po did not change.