Molecular Genetic Analysis of the ABO Blood Group System: 4. Another Type of O Allele

• DOI: 10.1111/j.1423-0410.1993.tb05158.x
• Publication Date: 2009-03-05T20:38:15Z
• Authors: Fumi‐ichiro Yamamoto; Patricia D. McNeill; Miyako Yamamoto; Sen‐itiroh Hakomori; Imelda M. Bromilow; Jennifer K. M. Du...
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Base Sequence; Genetic Code; Molecular Sequence Data; Humans; Exons; Alleles; ABO Blood-Group System

Abstract We have encountered an allele which seems to be another type of O at the human histo‐blood group ABO locus. determined nucleotide sequence this over coding region in last two exons. This does not possess single‐nucleotide deletion found common among all alleles previously analyzed. Compared with A 1 allele, has three substitutions resulting amino acid substitutions. The introduction these into transferase expression construct apparently abolished enzymatic activity transferase.