Regulation of Rat-Liver Tyrosine-Aminotransferase mRNA by Hydrocortisone and by N6,O2'-Dibutyryladenosine 3',5'-Phosphate

• DOI: 10.1111/j.1432-1033.1980.tb04730.x
• Publication Date: 2005-03-03T20:21:26Z
• Authors: Martin DIESTERHAFT; Daryl GRANNER; Tamio NOGUCHI
• Keywords: Tyrosine aminotransferase

The intraperitoneal injection of either hydrocortisone or N6,O2′-dibutyryladenosine 3′,5′-phosphate (Bt2cAMP) results in a specific increase functional tyrosine aminotransferase mRNA (mRNATAT) activity rat liver that is proportional to the degree enzyme induction. Both require continuous RNA synthesis. There are several differences response these inducers: (a) magnitude greater following than after Bt2cAMP; (b) peak seen within 1 h Bt2cAMP as compared 5 required for maximal injection; (c) finally, although both responses rapid, lag period which precedes accumulation at least 20 min whereas it 5–10 min. administration actinomycin D rats they were treated with causes an additional twofold enzymatic activity, phenomenon known superinduction, but does not prevent normal decrease its this time. This dissociation and activities indicates super-induction due selective stabilization codes protein.