Polymorphisms of interleukin‐10 and tumour necrosis factor‐α genes are associated with newly diagnosed and recurrent pulmonary tuberculosis

• DOI: 10.1111/j.1440-1843.2007.01108.x
• Publication Date: 2007-06-21T03:02:51Z
• Authors: Jae‐Hee OH; Chul‐Su YANG; Yeon‐Kyeong NOH; Yu‐Mi KWEON; Sung‐Soo JUNG; Ji Woong SON; Suck‐Jun KONG; Jang Uk YOON; Ji‐Sook LEE; Hwa‐Jung KIM; Jeong‐Kyu PARK; Eun‐Kyeong JO; Chang‐Hwa SONG
• Keywords: Genetic predisposition

Background and objectives: The genetic determinants for developing TB or having recurrent are unknown. present study investigated the relationship between susceptibility to tuberculosis human tumour necrosis factor‐α (TNF‐α) interleukin‐10 genes (IL‐10). Methods: A case–control was conducted using two groups of cases—newly diagnosed (N‐TB) (R‐TB)—and a control group. Results: One hundred seventeen healthy controls, 80 newly patients 65 with were enrolled. There no significant difference in TNF‐α−308 G/A genotype patient controls. IL‐10 −1082A alleles markedly over‐represented among compared subjects, however, there frequency N‐TB R‐TB groups. Conclusion: allele gene may be important determining TB, −308 TNF‐α does not affect differential susceptibility.