The associations amongeNOSG894T gene polymorphism, erectile dysfunction and related risk factors

• DOI: 10.1111/j.1464-410x.2007.07110.x
• Publication Date: 2007-09-17T05:47:02Z
• Authors: Yung‐Chin Lee; Chun‐Hsiung Huang; Chii‐Jye Wang; Chia‐Chu Liu; Wen‐Jeng Wu; Lin‐Li Chang; Hui‐Hui Lin
• Keywords: Male; Polymorphism, Genetic; Nitric Oxide Synthase Type III; Hypogonadism; Taiwan; DNA; Middle Aged; Severity of Illness Index; 3. Good health; Cohort Studies; Diabetes Complications; 03 medical and health sciences; 0302 clinical medicine; Erectile Dysfunction; Risk Factors; Case-Control Studies; Humans; Regression Analysis; Genetic Predisposition to Disease; Alleles

OBJECTIVETo investigate the possible correlations amongeNOSG894T polymorphism, erectile dysfunction (ED) and related risk factors in a Taiwanese population.MATERIALS AND METHODSIn all, 151 patients with ED and 77 healthy controls were enrolled. All the men had a complete clinical history taken and laboratory data was collected. To assess erectile conditions the five‐item version of the International Index of Erectile Function (IIEF‐5) was used. TheeNOSG894T polymorphisms were determined using the polymerase chain reaction‐restriction fragment length polymorphism method.RESULTSIn all, 228 men were enrolled with a mean (sd) age of 58.6 (9.7) years. In a univariate analysis, age, serum testosterone level, and the prevalence of diabetes mellitus (DM) and hypertension were significantly different between patients with ED and the healthy controls (P < 0.01). In the multiple logistic regression analysis, DM, age and hypogonadism were three independent risk factors for ED (P = 0.018,P = 0.046 andP = 0.016, respectively). The prevalence of ED in T allele carriers (GT/TT) was significantly greater than in G allele carriers (GG; 80.0% vs 63.3%,P = 0.04). Also theeNOS894T allele carriers had significantly lower IIEF‐5 scores than theeNOS894G allele carriers, at 13.2 (5.3) vs 15.7 (6.1) (P = 0.01) and it was associated with increment of T allele number (11.0 (5.6) vs 13.6 (5.2) vs 15.7 (6.1);P = 0.03).CONCLUSIONOur results indicate that DM, age and hypoganadism are three significant independent risk factors for ED. Also, in the Taiwanese population, theeNOS894T allele carriers are at greater risk of ED, both in prevalence and severity, and this might be a factor of genetic susceptibility.