Islet Function and Insulin Sensitivity in the Non‐diabetic Offspring of Conjugal Type 2 Diabetic Patients

• DOI: 10.1111/j.1464-5491.1990.tb01345.x
• Publication Date: 2009-07-30T10:25:04Z
• Authors: C. Johnston; W.K. Ward; J.C. Beard; B. McKnight; D. Porte
• Keywords: Adult; Blood Glucose; Male; Body Weight; Glucose Tolerance Test; Arginine; Glucagon; 3. Good health; Islets of Langerhans; 03 medical and health sciences; 0302 clinical medicine; Diabetes Mellitus, Type 2; Reference Values; Insulin Secretion; Glucose Clamp Technique; Humans; Insulin; Female

To determine whether the genetic predisposition towards Type 2 diabetes was associated with a defect in either islet‐cell function or insulin action, 12 non‐diabetic offspring each of whose parents both had were studied, together control subjects matched for age, sex, and weight. Fasting plasma glucose higher (5.5 ± 0.1 mmol I −1 (mean SE)) than controls (5.1 ) ( p < 0.05). Using an IVGTT sensitivity not significantly lower compared their (3.1 0.5 vs 3.8 1.0 min ***mU 10 −4 ). There no significant difference any measures secretion (first‐ second‐phase response to IV glucose, slope potentiation, maximal regulated secretory capacity). Glucagon measured before after stimulus arginine at varying concentrations virtually identical controls. Among total 28 differing body‐weights there inverse relationship between secretion. When adjusted generally sensitivity, capacity reduced = 0.038, one‐tailed t ‐test). The results suggest that is young adults major pre‐morbid impairment action but two may be abnormal. Islet A‐cell appears normal.