The PRIPS study: screening battery for subjects at risk for Parkinson's disease

• DOI: 10.1111/j.1468-1331.2012.03798.x
• Publication Date: 2012-08-02T00:18:47Z
• Authors: D. Berg; J. Godau; K. Seppi; S. Behnke; I. Liepelt‐Scarfone; S. Lerche; H. Stockner; A. Gaenslen; P. Mahlknecht; H. Huber; K. Srulijes; J. Klenk; K. Fassbender; W. Maetzler; W. Poewe
• Keywords: Hyposmia

Background and purpose Screening batteries to narrow down a target‐at‐risk population are essential for trials testing neuroprotective compounds aiming delay or prevent onset of P arkinson's disease ( PD ). Methods The PRIPS study focuses on early detection incident in 1847 at baseline ‐free subjects, assessed age, male gender, positive family history, hyposmia, subtle motor impairment enlarged substantia nigra hyperechogenicity SN +). Results After 3 years follow‐up 11 subjects had developed . In this analysis the secondary outcome parameters, sensitivity specificity markers were calculated 1352 with complete datasets (10 patients). best approach prediction comprised three steps: (i) prescreening (ii) primary screening history and/or (iii) +. Conclusion With approach, one out 16 positively screened participants compared 135 original cohort. This corresponds 80.0%, 90.6% predictive value 6.1%. These values higher than any single instrument but still too low feasible cost‐effective strategy which might require longer intervals application additional instruments.