Proximity of brain infarcts to regions of endogenous neurogenesis and involvement of striatum in ischaemic stroke

• DOI: 10.1111/j.1468-1331.2012.03877.x
• Publication Date: 2012-10-11T15:21:33Z
• Authors: H. Delavaran; H. Sjunnesson; A. Arvidsson; O. Lindvall; B. Norrving; D. van Westen; Z. Kokaia; A. Lindgren
• Keywords: Stroke; Putamen

Background and purpose Clinical stroke trials with stem cell‐based approaches aiming for trophic actions, modulation of inflammation neuroprotection are ongoing. However, experimental studies also suggest that neuronal replacement by grafted neural cells ( NSC s) possibly endogenous s from the subventricular zone SVZ ) may restore function in stroke‐damaged striatum. To evaluate potential clinical impact these findings, we analyzed spatial relationship infarcts to proportion individuals striatal lesions a consecutive series ischaemic patients. Methods Patients aged 20–75 years first‐ever underwent DW ‐ MRI brain within 4 days after onset. We location, size, number acute focal abnormalities their . Stroke severity was assessed using NIH Scale NIHSS ). Results Of 108 included patients, distance nearest margin infarct(s) ≤2 mm 51/102 patients visible on Twenty‐four had involvement Eight predominantly lesions, is >50% total lesion volume located caudate nucleus and/or putamen. These 8 median 3. Conclusions Many have close , providing some supportive evidence optimized neurogenesis therapeutic potential. rare tend give mild neurological deficits, indicating striatum should not be primary target efforts humans.