European Gene Mapping Project (EUROGEM): Breakpoint panels for human chromosomes based on the CEPH reference families

• DOI: 10.1111/j.1469-1809.1996.tb01614.x
• Publication Date: 2007-09-28T10:01:51Z
• Authors: S. A. COX; J. ATTWOOD; S. P. BRYANT; R. BAINS; S. POVEY; M. REBELLO; M. KAPSETAKI; N. K. MOSCHONAS; K.‐H. GRZESCHIK; M. OTTO; M. DIXON; H. E. SUDWORTH; R. F. KOOY; A. WRIGHT; P. TEAGUE; L. TERRENATO; G. VERGNAUD; S. MONFOUILLOUX; J. WEISSENBACH; O. ALIBERT; C. DIB; S. FAURÉ; E. BARKER; N. M. PEARSON; R. H. A. M. VOSSEN; A. GAL; B. MUELLER‐MYHSOK; H. M. CANN; N. K. SPURR
• Keywords: 0303 health sciences; 03 medical and health sciences; RESOLUTION; HOMOZYGOUS DELETION; ALLELIC LOSS; HUMAN GENOME; BREAST-CANCER; LOCALIZATION; CONSORTIUM LINKAGE MAP; POSITIONAL CLONING; MELANOMA KINDREDS; REGION

SummaryMeiotic breakpoint panels for human chromosomes 2, 3, 4, 5, 6, 7, 8, 9, 10, 13, 14, 15, 17, 18, 20 and X were constructed from genotypes from the CEPH reference families. Each recombinant chromosome included has a breakpoint well‐supported with reference to defined quantitative criteria. The panels were constructed at both a low‐ resolution, useful for a first‐pass localization, and high‐resolution, for a more precise placement. The availability of such panels will reduce the number of genotyping experiments necessary to order new polymorphisms with respect to existing genetic markers. This paper shows only a representative sample of the breakpoints detected. The complete data are available on the World Wide Web URL (http:www.icnet.ukaxphgreurogemHTMLdata.html) or by anonymous ftp (ftp.gene.ucl.ac.uk inpubeurogemmapsbreakpoints).